Analysis of Neisseria lactamica antigens putatively implicated in acquisition of natural immunity to Neisseria meningitidis
نویسندگان
چکیده
منابع مشابه
Nasopharyngeal colonization by Neisseria lactamica and induction of protective immunity against Neisseria meningitidis.
BACKGROUND Natural immunity to Neisseria meningitidis may result from nasopharyngeal carriage of closely related commensals, such as Neisseria lactamica. METHODS We enrolled 61 students with no current carriage of Neisseria species and inoculated them intranasally with 10,000 colony-forming units of Neisseria lactamica or sham control. Colonization was monitored in oropharyngeal samples over ...
متن کاملcomparative proteomics analysis of two strains of neisseria meningitidis serogroup b and neisseria lactamica
conclusions these results show the usefulness of proteome analysis in successful identification of the common proteins between n. lactamica strains and nmb. this proteomics analysis is the starting point in the path of knowledge development about whole proteome profiles of n. lactamica strains. objectives the main aims of this study were to determine whole proteome profiles of n. lactamica stra...
متن کاملHomology of cryptic plasmid of Neisseria gonorrhoeae with plasmids from Neisseria meningitidis and Neisseria lactamica.
DNA probe hybridisation was used to examine the relation between the cryptic plasmid from Neisseria gonorrhoeae and plasmids carried by pharyngeal isolates of Neisseria meningitidis and Neisseria lactamica. The complete gonococcal cryptic plasmid and HinfI derived digestion fragments subcloned into Escherichia coli were used to probe Southern blots of plasmid extracts. Homology was found to a p...
متن کاملComparative Proteomics Analysis of Two Strains of Neisseria meningitidis Serogroup B and Neisseria lactamica
BACKGROUND Antigenic similarities between Neisseria lactamica as a commensal species and N. meningitidis serogroup B (NmB) as an important cause of meningitis infection have been considered for the development of an effective vaccine based on their common proteins to prevent life-threatening bacterial meningitis. OBJECTIVES The main aims of this study were to determine whole proteome profiles...
متن کاملBioinformatic analysis of outer membrane proteome of Neisseria meningitidis and Neisseria lactamica.
Two-dimensional electrophoresis (isoelectric focusing/SDS-PAGE) and Western-blotting techniques were used to analyze and compare common and/or specific outer-membrane proteins and antigens from Neisseria meningitidis and Neisseria lactamica. Bioinformatic image analyses of proteome and immunoproteome maps indicated the presence of numerous proteins and several antigens shared by N. meningitidis...
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ژورنال
عنوان ژورنال: FEMS Immunology and Medical Microbiology
سال: 2002
ISSN: 0928-8244
DOI: 10.1016/s0928-8244(02)00326-7